Composition of matter
AssigneeAstraZeneca AB
InventorsMikael Bisrat, Saeed Moshashaee, Håkan Nyqvist, Mustafa Demirbüker
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Abstract
The invention provides a process for crystallization of amorphous and/or meta-stable crystalline regions of preformed particles by treating the particles with a supercritical or subcritical fluid containing an anti-solvent and a solvent. The invention further provides formulations comprising particles produced according to the present process containing one or more pharmacologically active substances and one or more pharmaceutically acceptable excipients, use of said formulations in the treatment of an allergic and/or inflammatory condition of the nose or lungs and methods for treatment of such conditions.
Claims26
A process for the preparation of essentially crystalline particles, comprising:
- (a) placing preformed particles having amorphous and/or meta-stable crystalline regions in an apparatus suitable for supercritical or subcritical conditions;
- and
- (b) treating the particles with a supercritical or subcritical fluid comprising an anti-solvent and a solvent to form the essentially crystalline particles.
The process according to any previous claim, wherein the process is conducted at a pressure in the range of from about 10 up to about 300 bar higher than the critical pressure (Pc) of the anti-solvent.
Dependencies are inferred from the claim text.