Powders comprising anti-adherant materials for use in dry powder inhalers
AssigneeVectura Limited
InventorJohn Nicholas Staniforth
Life of this patent
Estimating the term…
Abstract
A powder for use in a dry powder inhaler comprises active material and additive material. The additive material comprises an anti-adherent material and the powder includes at least 60% by weight of active material. The inclusion of the additive material in the powder has been found to give an increased respirable fraction of the active material.
Claims24
A powder for use in a dry powder inhaler, the powder comprising active material and additive material, the additive material comprising an anti-adherent material including one or more compounds selected from amino acids and derivatives thereof, and peptides and polypeptides having a molecular weight of between about 0.25 to 1000 kDa, and derivatives thereof, and the powder including at least 60% by weight of active material based on the weight of the powder and further including not more than 10% by weight of additive material based on the weight of the powder, in which at least 90% by weight of the powder particles have a particle size of less than 63 μm.
A powder for use in a dry powder inhaler the powder comprising a β2-agonist as an active material and additive material comprising an anti-adherent material selected from leucine, L-leucine, D-leucine, DL-leucine, isoleucine, valine, methionine, cysteine, phenylalanine, and mixtures thereof, at least 95% by weight of the powder particles having a particle size of less than 10 μm, the powder including at least 60% by weight of active materials based on the weight of the powder, and further including not more than 10% by weight of additive material based on the weight of the powder.
A dry powder inhaler including a powder comprising an active material, and an additive material, the additive material comprising an anti-adherent material selected from lecithin, leucine, L-leucine, D-leucine, DL-leucine, isoleucine, valine, methionine, cysteine and phenylalanine, and the powder including at least 60% by weight of active material based on the weight of the powder and further including not more than 40% by weight of additive material based on the weight of the powder, in which at least 95% by weight of the active particles have a particle size less than 10 μm.
Dependencies are inferred from the claim text.