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US 6,475,519 B1Granted
Oil-free pharmaceutical compositions containing cyclosporin A
AssigneeNovartis AG
InventorsArmin Meinzer, Barbara Haeberlin
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Abstract
The present invention provides a hard gelatine capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with a surfactant of HLB value of at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic phase being a polyethylene glycol and/or a lower alkanol provided that any lower alkanol, if present, is present in less than 12% of the total weight of the composition absent the hard gelatine capsule.
Claims11
A hard gelatine capsule containing a pharmaceutical composition comprising:
- a) cyclosporin A;
- b) polyethyloxylated castor oil having an HLB value of at least 10;
- and
- c) a polyethylene glycol and a lower alkanol, wherein the polyethylene glycol is present in an amount of 1 to 40 weight percent, and each loweralkanol is present in an amount of less than 12 weight percent, wherein the weight percents are based on the total weight of the composition disregarding the hard gelatine capsule.
1 more element
Dependencies are inferred from the claim text.