Methods and compositions for treatment of disorders associated with chlamydia and similar bacterial infection

A method for the treatment or prevention of a condition associated with infection by microorganisms selected from the group consisting of Chlamydia species, Mycoplasma species, Listeria species, Bartonella species, and the aetiologic agents of leptospirosis and Q fever in a patient in need of such treatment or prevention, the method comprising the administration to the patient of an effective amount of at least three different antibiotics, each antibiotic being from a different class, selected from the group consisting of tetracyclines, macrolides, quinolones, chloramphenicol, rifamycins, sulfonamides, co-trimoxazole and oxazolidinones.

At least two different antibiotics or antimicrobial agents selected from the group consisting of tetracyclines, macrolides, quinolones, rifamycins, sulfonamides, co-trimoxazole and oxazolidinones, when used for the treatment or prevention of a condition associated with infection by microorganisms selected from the group consisting of Chlamydia species, Mycoplasma species, Listeria species, Bartonella species, and the aetiologic agents of leptospirosis and Q fever in a patient in need of such treatment.

A pharmaceutical composition for the treatment of a condition associated with infection by microorganisms selected from the group consisting of Chlamydia species, Mycoplasma species, Listeria species, Bartonella species, and the aetiologic agents of leptospirosis and Q fever in a patient in need of such treatment, the composition comprising at least two different antibiotics or antimicrobial agents selected from the group consisting of tetracyclines, macrolides, chloramphenicol, rifamycins, sulfonamides, co-trimoxazole and oxazolidinones, with the proviso that said composition is not a composition which includes both chloramphenicol and a tetracycline, said pharmaceutical composition being suitable for oral administration.

A pharmaceutical composition for the treatment of a condition associated with infection by microorganisms selected from the group consisting of Chlamydia species, Mycoplasma species, Listeria species, Bartonella species, and the aetiologic agents of leptospirosis and Q fever in a patient in need of such treatment, the composition comprising at least two different antibiotics or antimicrobial agents selected from the group consisting of tetracyclines, macrolides, chloramphenicol, sulfonamides, co-trimoxazole and oxazolidinones and not including a rifamycin;

• with the proviso that said composition is not a composition which includes both chloramphenicol and a tetracycline;
• said composition being suitable for oral administration.

A pharmaceutical composition for the treatment of a condition associated with infection by microorganisms selected from the group consisting of Chlamydia species, Mycoplasma species, Listeria species, Bartonella species, and the aetiologic agents of leptospirosis and Q fever in a patient in need of such treatment, the composition comprising a first antibiotic or antimicrobial agent selected from the group consisting of azithromycin, clarithromycin and roxithromycin, a second antibiotic or antimicrobial agent which is rifampicin, and a third antibiotic or antimicrobial agent selected from doxycycline and ofloxacin, said composition being suitable for oral administration.

A pharmaceutical composition comprising a first antibiotic or antimicrobial agent provided with a first pharmaceutically acceptable coating and at least a second antibiotic or antimicrobial agent optionally provided with a second pharmaceutically acceptable coating, said antibiotics or antimicrobial agents being selected from the group consisting of tetracyclines, macrolides, quinolones, chloramphenicol, rifamycins, sulfonamides, co-trimoxazole and oxazolidinones;

• with the proviso that said composition is not a composition which includes both chloramphenicol and a tetracycline.