Drug delivery via therapeutic hydrogels
OwnerFrank DiCosmo, Valerio DiTizioinventors
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Abstract
The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.
Claims17
A medical device comprising:
- a. a wound dressing having a polymeric surface;
- b. a gelatin hydrogel matrix material;
- and
- c. a therapeutic agent encapsulated in liposomes within said matrix material, wherein said gelatin hydrogel matrix material is affixed to the polymeric surface of said wound dressing by a plurality of covalent bonds.
A method for the treatment of wound closures from infection, said method comprising applying a wound dressing sheet having a polymeric surface to a wound closure, wherein said polymeric surface has a plurality of covalent bonds connecting said wound dressing sheet with a surface of a layer of a gelatin-based therapeutic hydrogel matrix.
A wound dressing sheet comprising:
- a. a essentially flat polymeric surface;
- b. a gelatin hydrogel matrix material;
- and
- c. a therapeutic agent encapsulated in liposomes within said matrix material, wherein said gelatin hydrogel matrix material is affixed to the external polymeric surface of said wound dressing sheet by a plurality of covalent bonds.
A method for the treatment and prevention of an infection, said method comprising:
- providing a biofilm comprising a wound dressing having an essentially flat polymeric external surface, a gelatin hydrogel matrix material affixed to the external polymeric surface of said wound dressing sheet by a plurality of covalent bonds and a therapeutic agent encapsulated in liposomes within said matrix material;
- and
- applying said biofilm to a wound closure.
Dependencies are inferred from the claim text.