Treatment of HIV and other viral infections using combinatorial therapy
AssigneeTrimeris, Inc.
InventorsM. Ross Johnson, Dennis Michael Lambert
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Abstract
Novel antiviral combinations for the treatment or prevention of viral infections, in particular, HIV, are disclosed. This new antiviral therapy employs either DP-178 or DP-107, viral fusion inhibitors, in combination with at least one other antiviral therapeutic agent. The combinations of the invention are better than single therapies alone, and in certain cases are synergistic. The use of DP-178 or DP-107 is an ideal therapy to combine with another antiviral, given both the novel mechanism which this therapeutic blocks HIV transmission and the non-toxicity of the therapeutic.
Claims32
A method of treating HIV-1 infection in a subject, comprising administering to the subject a therapeutically effective amount of DP-178 having SEQ ID NO:1, or a pharmaceutically acceptable derivative thereof, and a therapeutically effective amount of at least one other therapeutic agent which is a reverse transcriptase inhibitor or an inhibitor of HIV-1 protease.
A method of inhibiting HIV-1 replication in a subject, comprising administering to the subject a therapeutically effective amount of DP-178 having SEQ ID NO:1, or a pharmaceutically acceptable derivative thereof, and a therapeutically effective amount of at least one other therapeutic agent which is a reverse transcriptase inhibitor or an inhibitor of HIV-1 protease.
A pharmaceutical composition useful for the treatment of HIV-1 infection, comprising a therapeutically effective amount of DP-178 having SEQ ID NO:1, or a pharmaceutically acceptable derivative thereof, a therapeutically effective amount of at least one other therapeutic agent which is a reverse transcriptase inhibitor or an inhibitor of HIV-1 protease, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.