Methods of inhibiting angiogenesis and ameliorating cancer by using superfibronectin
AssigneeThe Burnham Institute
InventorsRenata Pasqualini, Erkki Ruoslahti
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Abstract
The invention provides a method of inhibiting angiogenesis and treating pathologies with angioproliferative components. The invention provides a method of ameliorating tumor growth and metastasis in a subject comprising administering a superfibronectin or a superfibronectin-generating compound to the subject. The invention also provides a method of inhibiting the migration and attachment of tumor cells.
Claims12
A method of inhibiting cancer in a subject, comprising administering a superfibronectin-generating compound to the subject, wherein said superfibronectin-generating compound comprises a III1-C or III-1C polypeptide fragment of fibronectin consisting of SEQ ID NO:
- 3.
A method of inhibiting cancer in a subject, comprising administering a superfibronectin-generating compound to the subject, wherein said superfibronectin-generating compound is selected from the group consisting of SEQ ID NOS:
- 2, 3, and 6.
A pharamaceutical composition, comprising a superfibronectin-generating compound and a pharmaceutically acceptable carrier, wherein said superfibronectin-generating compound consists of SEQ ID NO:
- 2.
A pharamaceutical composition comprising a superfibronectin-generating compound and a pharmaceutically acceptable carrier, wherein said superfibronectin-generating compound is selected from the group consisting of SEQ ID NOS:
- 2, 3, and 6.
Dependencies are inferred from the claim text.