Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates

A fusion protein for prodrug activation of the formula huTuMab-L-β-Gluc, where huTuMab is a tumor-binding fragment of a humanized monoclonal antibody wherein the tumor-binding fragment huTuMab comprises a VH region, a CH1 region, and at least one hinge region, L is a peptide linker which comprises a hinge region, and β-Gluc is human β-glucuronidase.