Radio-opaque polymer biomaterials
AssigneeRutgers, The State University
InventorsJoachim B. Kohn, Durgadas Bolikal, Sanyog M. Pendharkar
Life of this patent
Estimating the term…
Abstract
Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.
Claims80
A radio-opaque polymer characterized by having the structure:
- wherein X1 and X2 are independently I or Br, Y1 and Y2 are independently 0, 1 or 2, R7 is independently an alkylene group containing up to 4 carbon atoms;
- R9 and R12 are independently an alkyl, aryl or alkylaryl group containing up to 18 carbon atoms;
- A is:
- wherein R8 is selected from the group consisting of saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;
- k is between about 5 and about 3,000, and f and g are independently between 0 and 0.99, inclusive.
A radio-opaque polymer characterized by the structure:
- wherein:
- (a) R5 and R6 are independently selected from the group consisting of H, Br, I, and straight and branched alkyl groups having up to 18 carbon atoms;
- and R16 and R17 are independently selected from the group consisting of H and straight and branched alkyl groups having up to 18 carbon atoms, provided that when g is zero, R1 and R2 are independently Br or I unless R15 is —CJ1—CJ2— or Z is a carboxylic acid amide;
- (b) R15 is selected from the group consisting of (—CH2—)c, —CH═CH— and —CHJ1—CHJ2—, wherein J1 and J2 are independently Br or I and c is between 0 and 8, inclusive;
- (c) X2 is Br or I and Y2is 1 or 2;
- (d) Z is selected from the group consisting of H, a free carboxylic acid group or an ester or amide thereof;
- (e) each R7 is an alkylene group containing up to four carbon atoms, with k being between about 5 and about 3000;
- (f) A is:
- wherein R8 is selected from the group consisting of saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;
- (g) each R0 is independently —CH═CH— or (—CH2—)d, wherein d is between 0 and 8, inclusive;
- and
- (h) f and g independently range from 0 to less than 1.
Dependencies are inferred from the claim text.