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US 6,475,470 B1Granted
Compositions for oral cavity
AssigneeKao Corporation
InventorsShigeto Kayane, Yoshitaka Yanou, Hidetake Fujinaka, Hidenori Yoshida, Yoshinori Murakami, Akira Suzuki, Koji Maeda
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Abstract
This invention relates to compositions for the oral cavity, each of which comprises (A) a pharmaceutically-active agent, which acts on the periodontium, or a microbicidal agent and (B) an exothermic ingredient or a water-soluble high-molecular substance, and has a water content not higher than 5 wt. %. They permit adsorption of a pharmaceutically-active agent or the like at a high rate on the oral mucosas and are excellent in the effects of preventing and/or treating paradental diseases.
Claims15
A composition for the oral cavity, comprising
- (A) a pharmaceutically-active agent, which acts on the periodontium, or a microbicidal agent,
- (B) 20-50 wt. % of an exothermic ingredient,
- (C) 0.1-2 wt. % of a water-soluble polymeric substance, and
- (D) an alkaline earth metal salt,
- wherein said composition has a water content not higher than 5 wt. %,
- said pharmaceutically-active agent or said microbicidal agent is present in an amount effective for preventing and/or treating paradental disease and an amount which is less than an amount used for preventing and/or treating paradental disease in the absence of said exothermic ingredient, and
- wt. % is based on a total weight of said composition.
4 more elements
Dependencies are inferred from the claim text.