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US 6,475,468 B2Granted
Modulated release particles for aerosol delivery
AssigneeAeropharm Technology Incorporated
InventorsYaping Zhu, Simon G. Stefanos, Lukeysha Kline, Akwete L. Adjei
Life of this patent
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Abstract
A modulated release aerosol formulation is disclosed. The formulation comprises a polymer, e.g. Silica gel, fumed silica gel, having a selected medicament associated therewith, and a fluid carrier for carrying and delivering the construct.
Claims13
A modulated release aerosol formulation, which consists essentially of:
- a. a polymeric construct of a polysaccharide polymer selected from the group consisting of an alginic acid or a pharmaceutically acceptable salt thereof;
- guar gum;
- gum Karaya;
- gum Benjamin;
- plantago ovata gum;
- agar;
- carrageenan;
- gelatin;
- gumaribic;
- pectin;
- galaturonic acid or a mixture of any of the foregoing polymers, having a selected medicament associated therewith;
- and
- b. a fluid carrier for carrying and delivering said construct.
10 more elements
A modulated release aerosol formulation, which consists essentially of:
- a. a selected particulate medicament;
- b. particles of a polysaccharide polymer selected from the group of consisting of an alginic acid or a pharmaceutically acceptable salt thereof;
- guar gum;
- gum Karaya;
- gum Benjamin;
- plantago ovata gum;
- agar;
- carrageenan;
- gelatin;
- gumaribic;
- pectin;
- galaturonic acid or a mixture of any of the foregoing polymers, having said medicament associated therewith;
- and
- c. a fluid carrier for carrying and transporting said particles of polymer.
11 more elements
A metered dose inhaler containing a medicinal formulation, the formulation consisting essentially of:
- a. a particulate medicament in a therapeutically effective amount;
- b. a polysaccharide polymer selected from the group consisting of an alginic acid or a pharmaceutically acceptable salt thereof;
- guar gum;
- gum Karaya;
- gum Benjamin;
- plantago ovata gum;
- agar;
- carrageenan;
- gelatin;
- gumaribic;
- pectin;
- galacturonic acid or a mixture of any of the foregoing polymers with which said particulate medicament is associated to form a particulate polymeric construct;
- and
- c. a fluid carrier for containing and transporting said particulate polymeric construct.
11 more elements
A modulated release aerosol formulation, which comprises,
- a. a selected particulate medicament;
- b. particles of a polysaccharide polymer selected from the group consisting of an alginic acid or a pharmaceutically acceptable salt thereof;
- guar gum;
- gum Karaya;
- gum Benjamin;
- plantago ovata gum;
- agar;
- carrageenan;
- cellulose;
- gelatin;
- gumaribic;
- pectin;
- galaturonic acid or a mixture of any of the foregoing polymers having said medicament associated therewith;
- c. a fluid carrier for carrying and transporting said particles of polymer;
- and
- d. a stabilizer selected from the group consisting of (1) a first stabilizer selected from the group consisting of (a) an amino acid, (b) a derivative thereof and (c) a mixture of the foregoing;
- and (2) a second stabilizer of a water addition and (3) a mixture of (1) and (2).
14 more elements
Dependencies are inferred from the claim text.