Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
AssigneeUT-Battelle, LLC
InventorJ. Michael Ramsey
Life of this patent
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Abstract
A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.
Claims31
A method of controlling movement of a material in a fluid in a microscale channel system, comprising providing at least first, second, third and fourth fluid filled reservoirs in fluid communication with each other through a microscale channel system;
- and simultaneously applying selected voltages at least to said first, second and third fluid reservoirs and controlling voltage at said fourth reservoir, thereby controlling material movement in the microscale channel system.
Dependencies are inferred from the claim text.