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US 6,473,639 B1Granted
Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures
AssigneeNeuroPace, Inc.
InventorsDavid R. Fischell, Jonathan Harwood, Benjamin D. Pless
Life of this patent
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Abstract
This invention relates generally to information processing techniques used in the treatment of epilepsy and to devices for using these techniques.
Claims119
A device for detection of neurological event activity in a patient's brain comprising:
- at least one brain electrode configured to monitor brain electrical signals and produce an output, each said brain electrode being positionable to a position relative to a patient's brain,
- at least one processed display channel processor configured to produce at least one processed display channel, said at least one processed display channel being a signal produced by signal processing by said at least one processed display channel processor, of a digital signal related to said output from said at least one brain electrode, the signal processing having one or more parameters;
- a neurological event detector configured to process the at least one processed display channel with at least one detector algorithm to detect neurological event activity based upon i.) the brain electrical signals received by the at least one brain electrode, ii.) the position of each brain electrode, iii.) the parameters of the signal processing used to create the at least one processed display channel, iv.) and at least one detector algorithms having at least one detector parameter customizeable for each patient.
An implantable neuropacemaker assembly comprising:
- a multiplicity of intracranially placeable leads for delivering electrocortigram signals;
- at least one amplifier for amplifying the electrocortigram signals and produce amplified electrocortigram signals;
- at least one analog-to-digital converter for digitizing the amplified electrocortigram signals to produce a multiplicity of digital signals;
- at least one signal processor configured to produce one or more processed display channels, each processed display channel being a signal produced by the combination of one or more of the multiplicity of digital signals by signal processing with an algorithm having signal processing parameters;
- and
- at least one epileptiform event detector device configured to process said one or more processed display channel with programmable algorithms to detect epileptiform activity.
3 more elements
A device for detecting an epileptiform activity from a multiplicity of digitized EEG signals comprising:
- at least one processed display channel processor configured to produce at least one processed display channel by signal processing of at least one of the multiplicity of digitized EEG signals, said signal processing having one or more parameters;
- at least one epileptiform activity detector having at least one detector algorithm operating on the at least one processed display channel, the epileptiform activity detector having at least one programmable detection parameter, the epileptiform activity detector being configured to detect epileptiform activity based upon i.) the at least one processed display channel signal, ii.) the parameters of the signal processing used to create the at least one processed display channel, and iii.) said at least one detector algorithm having at least one detector parameter customizable for each patient.
A device for diagnosis of, testing for, and treatment of epileptic seizures of a human patient, the device comprising:
- a multiplicity of brain electrodes configured to receive neural electrical signals generated by the brain of the human patient;
- conductors for carrying electrical signals to and from the multiplicity of brain electrodes;
- a physician's workstation configured to detect the presence of epileptiform activity by signal processing of at least one electrical signal received by the multiplicity of brain electrodes, the signal processing including analyzing a processed display channel using a processed display channel based seizure detector, the processed display channel based seizure detector having seizure detector parameters adjustable by a user best to detect epileptiform activity for a selected human patient;
- an implantable neuropacemaker configured to detect the presence of epileptiform activity by processing of at least one electrical signal received by the multiplicity of brain electrodes into at least one processed display channel and analysis of the at least one processed display channel for epileptiform activity using seizure detector having seizure detector parameters;
- and
- a transmitter configured to transmit to the neuropacemaker, the seizure detector parameters from the physician's workstation that have been selected to detect the epileptiform activity for the human patient.
3 more elements
A device for detection of epileptiform activity from a patient's brain comprising:
- at least one brain electrode, an amplifier, a digital to analog converter, and a processed display channel processor,
- wherein said at least one brain electrode is configured to electronically communicate signal information from a patient's brain to said amplifier, said amplifier being configured to amplify said signal information and produce amplified signals,
- wherein said analog to digital converter is configured to electronically receive said amplified signals from said amplifier and convert said amplified signals to digital signals,
- wherein said processed display channel processor is configured to process said multiple digital signals with an algorithm according to programmable algorithm rules to produce a processed display channel signal, said programmable algorithm rules being configured to produce a processed display channel signal clearly exhibiting characteristics of epileptiform activity within the patient's brain.
1 more element
An implantable neuropacemaker comprising:
- at least one intracranially placed lead, an amplifier, an analog to digital converter, a signal processor, and an epileptiform activity detector module,
- said intracranially placed lead being configured to receive EEG signals from the brain of a patient and transmit said signals to said amplifier,
- said amplifier being configured to amplify said signals and produce amplified signals,
- said analog to digital converter being configured to electronically receive said amplified signals and convert said amplified signals to a multiplicity of digital signals,
- said signal processor being configured to process said multiple digital signals according to programmable parameters to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain,
- said epileptiform activity detector module being configured to detect epileptiform activity based upon processing of said processed display channel signal using a detection algorithm.
3 more elements
A device for detecting an epileptiform activity from a multiplicity of digitized EEG signals comprising:
- one or more brain electrodes configured to receive EEG signals from the brain of a patient;
- one or more processed display channel processors to produce processed display channels, each processed display channel comprising one or more EEG signals combined using digital signal processing;
- an epileptiform activity detector having detector algorithms operating on said one or more processed display channels, the epileptiform activity detector being configured to detect epileptiform activity,
- wherein the position of each brain electrode, the parameters of the signal processing used to create the processed display channel, and the algorithms used by the epileptiform activity detector being customized for each patient.
1 more element
A device for diagnosis, testing, and treatment of epileptic seizures of a human patient, the device comprising:
- at least one intracranially placed lead, an amplifier, an analog to digital converter, a signal processor, and an epileptiform activity detection module,
- said intracranially placed lead being configured to receive EEG signals from the brain of a patient and transmit said signals to said amplifier,
- said amplifier being configured to amplify said signals and produce amplified signals,
- said analog to digital converter being configured to electronically receive said amplified signals and convert said amplified signals to a multiplicity of digital signals,
- said signal processor being configured to process said multiple digital signals according to programmable parameters to produce a processed display channel signal, said programmable parameters being configured to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain,
- said epileptiform activity detection module being configured to detect epileptiform activity based upon processing of said processed display channel signal;
- said amplifier, analog to digital converter, signal processor, and epileptiform activity detection algorithm comprising an implantable neuropacemaker module;
- said device further comprising a physician's workstation configured to transmit said programmable parameters to said implantable neuropacemaker module using a communication device.
5 more elements
A method for diagnosing and treating neurological disorders in a human patient comprising the steps of:
- signal processing digital signals related to a patient's EEG signals by combining said patient's EEG signals according to programmable parameters to produce processed display channel signals, the programmable parameters being selected to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain;
- and
- analyzing said processed display channel signal with an epileptiform activity detection algorithm configured to detect epileptiform activity based upon processing of said processed display channel signal.
Dependencies are inferred from the claim text.