Process for preparing a complex of a ligand, metal and base

Abstract

The present invention provides a process for the preparation of a chelant or chelating agent complex of the formula L•B•M. L is an amino acid derivative including two optically active amino acids are linked via a (CH2)n group, wherein the (CH2)n group is attached to a nitrogen of each optically active amino acid, the optically active amino acid may be the same or different; and wherein n is an integer from 1 to 10; B is a base; and M is a metal. The process comprises the steps of (i) providing a reaction mixture comprising L and B and having a pH of less than 7.5; (ii) contacting the reaction mixture with M to provide a first complex mixture; and (iii) contacting the first complex mixture with a further amount of B to provide a second complex mixture. The second complex mixture can further be sequentially contacted with further amounts of M and further amounts of B. Alternatively, the second complex mixture can be heated.

Dependencies are inferred from the claim text.