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US 6,472,545 B2Granted
Protein tyrosine phosphatase inhibitors
AssigneeAbbott Laboratories
InventorsGang Liu, Zhonghua Pei
Life of this patent
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Abstract
Compounds of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Claims10
A compound of formula (I)
- or a therapeutically acceptable salt thereof, wherein
- R1 is selected from the group consisting of benzodioxolyl, and dibenzofuranyl;
- wherein the benzodioxolyl and the dibenzofuranyl can be optionally substituted with one, two, three, or four substituents independently selected from the group consisting of alkanoyl, alkoxy, alkoxycarbonyl, alkyl, amino, aryl, arylalkyl, carbonyloxy, carboxy, cyano, cycloalkyl, cycloalkylalkyl, halo, hydroxy, hydroxyalkyl, nitro, perfluoroalkoxy, perfluoroalkyl, and thioalkoxy.
A compound selected from the group consisting of (2R)-2-(2,6-dichloro-4-dibenzo(b,d)furan-4-ylphenoxy)-3-phenylpropanoic acid, (2R)-2-(4-(1,3-benzodioxol-5-yl)-2,6-dichlorophenoxy)-3-phenylpropanoic acid.
Dependencies are inferred from the claim text.