Production process of diphosphine oxide and diphosphonate
AssigneeTakasago International Corporation
InventorsTohru Yokozawa, Takao Saito, Noboru Sayo, Takero Ishizaki
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Abstract
A process for producing a diphosphine oxide or diphosphonate represented by formula (1) as defined, which comprises treating, with a base, a phosphine compound represented by formula (2) as defined and adding the thus-treated phosphine compound to a nonpolar solvent having an oxidative metal compound suspended therein so as to effect dimerization. The present invention makes it possible to produce, conveniently, in a high yield and safely, a diphosphine oxide or diphosphonate which is an intermediate for producing a diphosphine compound useful as a ligand of a metal complex serving as a catalyst for asymmetric synthesis reaction.
Claims13
A process for producing a diphosphine oxide or diphosphonate represented by the following formula (1):
- wherein, R1 represents a C1-4 alkyl group, a C5-8 cycloalkyl group, a phenyl group, a substituted phenyl group substituted with 1 to 5 substituents which may be the same or different and each selected arbitrarily from the group consisting of C1-4 alkyl groups, C1-4 alkoxy groups and a phenyl group, a naphthyl group which may be substituted with a C1-4 alkyl group or a C1-4 alkoxy group, a C1-4 alkoxy group, a phenyloxy group, or a substituted phenyloxy group substituted with 1 to 5 substituents which may be the same or different and each selected arbitrarily from the group consisting of C1-4 alkyl groups, C1-4 alkoxy groups and a phenyl group, which comprises
- treating, with a base, a phosphine oxide or a phosphonate compound represented by the following formula (2):
- wherein, R1 has the same meaning as defined above, and
- adding the thus-treated phosphine compound to a solvent which consists essentially of a non-polar solvent having an oxidative metal compound suspended therein so as to effect dimerization.
Dependencies are inferred from the claim text.