Plasmodium falciparum antigens inducing protective antibodies
AssigneeInstitut Pasteur
InventorsPierre Druilhe, Hasnaq Bouharoun-Tayoun, Claude Oeuvray
Life of this patent
Estimating the term…
Abstract
A molecule, protein or peptide characterized in that it is recognized by cytophilic antibodies from individuals who are immune to infection by Plasmodia, and recognized by non-cytophilic antibodies from individuals who are vulnerable to infection by Plasmodiae. Said antibodies are capable of blocking the erythrocytic phase of the parasite by co-operating with accessory cells such as monocytes.
Claims21
An isolated DNA coding for a protein or peptide which is recognized by cytophilic antibodies of protected subjects (by premonition) against infection by the Plasmodia and recognized by non-cytophilic antibodies of subjects sensitive to the infection by the Plasmodia, wherein said cytophilic antibodies recognizing said protein or peptide inhibit the growth of the Plasmodia in an antibody-dependent cellular inhibition test (ADCI), and wherein said protein or peptide comprises SEQ ID NO:1.
An isolated DNA coding for a protein having a molecular weight of 48,000 daltons +/−10% and which is a surface protein of the merozoite of Plasmodium falciparum which is recognized by cytophilic antibodies of protected subjects (by premonition) against infection by the Plasmodia and recognized by non-cytophilic antibodies of subjects sensitive to the infection by the Plasmodia, wherein said cytophilic antibodies recognizing said protein or peptide inhibit the growth of the Plasmodia in an antibody-dependent cellular inhibition test (ADCI), and wherein the protein comprises a sequence selected from the group consisting of SEQ ID NO:2 SEQ ID NO:3, and SEQ ID NO:4.
An isolated nucleotide sequence comprising SEQ ID NO:
- 5.
An isolated nucleotide sequence which induces the synthesis of a peptide exhibiting an antigen cross-reaction with the protein of 48,000 daltons of the merozoites of Plasmodium falciparum, and which is selected from the group consisting of SEQ ID NO:
- 6, SEQ ID NO:
- 7, and SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.