Invasion associated genes from Neisseria meningitidis serogroup B
AssigneeCenters for Disease Control and Prevention, as represented by the Secretary, Department of Health and Human Services
InventorsEfrain M. Ribot, David S. Stephens, Nigel Raymond, Frederick D. Quinn
Life of this patent
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Abstract
Genes isolated from Neisseria memingitidis, as well as isolated nucleic acids, probes, expression cassettes, polypeptides, antibodies, immunogenic compositions, antisense nucleic acids, amplification mixtures, and new invasion deficient swains of Neisseria meningitidis are provided Methods of detecting Neisseria meningitidis and Neisseria meningitidis nucleic acids, and methods of inhibiting the invasion of mammalian cells by Neisseria meningitidis are also provided.
Claims7
An isolated nucleic acid encoding a polypeptide selected from the group of polypeptides consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:7.
An isolated nucleic acid which hybridizes under high stringency conditions to a nucleic acid selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, and SEQ ID NO:6 wherein the high stringency wash conditions are selected to be about 5° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH.
An isolated nucleic acid which hybridizes under high stringency conditions to SEQ ID NO:8 wherein the stringency wash conditions are selected to be about 5° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH.
Dependencies are inferred from the claim text.