Progestin-regulated gene
AssigneeGarvan Institute of Medical Research
InventorsColin Kenneth William Watts, Jenny Ann Hamilton
Life of this patent
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Abstract
Isolated DNA molecules are disclosed corresponding to a novel progestin-regulated gene (PRG1). The PRG1 polypeptide (PRG1) and uses thereof are also described, and include assays for assessing progestin-responsiveness in a subject.
Claims13
An isolated DNA molecule comprising a nucleotide sequence more than 80% homologous to any one of the nucleotide sequences shown at:
- (i) FIG. 2B (SEQ ID NO:1) from nucleotide 1 to 3018, and
- (ii) FIG. 2B (SEQ ID NO:1) from nucleotide 141 to 3018,
- wherein said DNA molecule encodes a protein with phosphofructo-2-kinase/fructose-2, 6-biphosphatase activity.
An isolated DNA molecule comprising a nucleotide sequence more than 90% homologous to any one of the nucleotide sequences shown at:
- (i) FIG. 2B (SEQ ID NO:1) from nucleotide 1 to 3018, and
- (ii) FIG. 2B (SEQ ID NO:1) from nucleotide 141 to 3018,
- wherein said DNA molecule encodes a protein with phosphofructo-2-kinase/fructose-2, 6-biphosphatase activity.
An isolated DNA molecule having the nucleotide sequence shown at FIG. 2B (SEQ ID NO:1) from nucleotide 1 to 3018, wherein said DNA molecule encodes a protein with phosphofructo-2-kinase/fructose-2, 6-biphosphatase activity or a nucleotide sequence complementary thereto.
An isolated DNA molecule having the nucleotide sequence shown at FIG. 2B (SEQ ID NO:1) from nucleotide 1 to 470, wherein said DNA molecule encodes a protein with phosphofructo-2-kinase/fructose-2, 6-biphosphatase activity or a nucleotide sequence complementary thereto.
An isolated DNA molecule having the nucleotide sequence shown at FIG. 2B (SEQ ID NO:1) from nucleotide 141 to 3018, wherein said DNA molecule encodes a protein with phosphofructo-2-kinase/fructose-2, 6-biphosphatase activity or a nucleotide sequence complementary thereto.
An isolated DNA molecule having the nucleotide sequence shown at FIG. 2B (SEQ ID NO:1) from nucleotide 470 to 2103, wherein said DNA molecule encodes a protein with phosphofructo-2-kinase/fructose-2, 6-biphosphatase activity.
A polypeptide in a substantially pure form, said polypeptide comprising an amino acid sequence as shown at FIG. 2B (SEQ ID NO:2) or an enzymatic portion thereof, wherein said polypeptide or enzymatic portion thereof has phosphofructo-2-kinase/fructose-2, 6-biphosphatase activity.
A polypeptide in a substantially pure form, said polypeptide consisting of an amino acid sequence as shown at FIG. 2B (SEQ ID NO:2) wherein said polypeptide or enzymatic portion thereof has phosphofructo-2-kinase/fructose-2, 6-biphosphatase activity.
Dependencies are inferred from the claim text.