Keratinocyte derived interferon
AssigneeHuman Genome Sciences, Inc.
InventorsDavid W. LaFleur, Paul A. Moore, Steven M. Ruben
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Abstract
The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide, called “KDI”. KDI polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of KDI activity. Also provided are therapeutic methods for treating immune system-related disorders.
Claims33
An isolated antibody or fragment thereof that specifically binds to an isolated protein having an amino acid sequence consisting of 28 to 207 of SEQ ID NO:2.
An isolated antibody or fragment thereof obtained from an animal that has been immunized with a protein having an amino acid sequence consisting of amino acid residues 28 to 207 of SEQ ID NO:2, wherein said antibody or fragment thereof specifically binds to said amino acid sequence.
An isolated monoclonal antibody or fragment thereof that specifically binds to a protein having an anino acid sequence consisting of 28 to 207 of SEQ ID NO:2.
An isolated antibody or fragment thereof that specifically binds a keratinocyte derived interferon protein purified from a cell culture wherein the cells in said cell culture comprise a polynucleotide encoding amino acids 28 to 207 of SEQ ID NO:2 operably associated with a regulatory sequence that controls gene expression.
Dependencies are inferred from the claim text.