Heteroarylacryloylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them

A compound of the formula (I),

• wherein
• R(1) is
• a) (C1-C4)-alkyl;
• or
• b) —O—(C1-C4)-alkyl, which is unsubstituted or is substituted by 1, 2, or 3 fluorine atoms;
• or
• c) —O—(C1-C4)-alkyl, which is substituted by a substituent chosen from nitro, ((C1-C4)-alkyl)carbonylamino, (C1-C4)-alkylamino, di((C1-C4)-alkyl)amino, hydroxycarbonyl, ((C1-C4)-alkoxy)carbonyl, piperidin-1-yl, morpholin-4-yl, tetrahydrofuranyl, tetrahydropyranyl, phenyl, and phenoxy;
• wherein the phenyl group and the phenoxy group are unsubstituted or are substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl;
• or
• d) —O—(C1-C4)-alkyl-E(1)-(C1-C4)-alkyl-D(1), in which D(1) is hydrogen or —E(2)-(C1-C4)-alkyl-D(2), in which D(2) is hydrogen or —E(3)-(C1-C4)-alkyl, wherein E(1), E(2), and E(3), which are independent of one another and can be identical or different, and are chosen from O, S, and NH;
• or
• e) —O—(C1-C4)-alkyl-O—(C1-C4)-alkyl, which is substituted by 1, 2, or 3 fluorine atoms;
• or
• f) —O—(C2-C4)-alkenyl;
• or
• g) —O-phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl;
• or
• h) halogen;
• or
• i) phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, —S(O)m—(C1-C4)-alkyl, phenyl, amino, hydroxyl, nitro, trifluoromethyl, cyano, hydroxycarbonyl, carbamoyl, ((C1-C4)-alkoxy)carbonyl, and formyl;
• or
• j) (C2-C5)-alkenyl, which is unsubstituted or is substituted by a substituent chosen from phenyl, cyano, hydroxycarbonyl, and ((C1-C4)-alkoxy)carbonyl;
• or
• k) (C2-C5)-alkynyl, which is unsubstituted or is substituted by a substituent chosen from phenyl and (C1-C4)-alkoxy;
• or
• l) 5-membered or 6-membered monocyclic heteroaryl having one or two identical or different ring heteroatoms chosen from oxygen, sulfur, and nitrogen;
• or
• m) —S(O)m-phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy and trifluoromethyl;
• R(2) is hydrogen or (C1-C6)-alkyl, but is not hydrogen if Z is oxygen;
• R(3) is hydrogen or (C1-C4)-alkyl;
• R(4) is hydrogen or (C1-C4)-alkyl;
• R(5) is hydrogen or (C1-C3)-alkyl, wherein any R(5) residue is independently chosen from any other R(5) residue;
• Het is 5-membered or 6-membered monocyclic heteroaryl having one or two identical or different ring heteroatoms chosen from oxygen, sulfur, and nitrogen, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, nitro, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl;
• X is oxygen or sulfur;
• Y is —(CR(5)2)n—;
• Z is NH or oxygen;
• m is 0, 1 or 2;
• and
• n is 1, 2, 3 or 4;
• or a stereoisomeric form of a compound of formula (I), or a mixture of at least two stereoisomeric forms of a compound of formula (I), or a physiologically tolerable salt of a compound of formula (I).