Advanced glycation end-product intermediaries and post-amadori inhibition
AssigneeUniversity of Kansas Medical Center
InventorsBilly G. Hudson, Parvin Todd, Raja Gabriel Khalifah, Aaron Ashley Booth
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Abstract
The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions.
Claims4
A method for treating or preventing proteinuria comprising administering to a mammal having an elevated blood sugar level an amount effective to prevent proteinuria of a compound of the general formula:
- wherein R1 is CH2NH2, CH2SH, COOH, CH2CH2NH2, CH2CH2SH, or CH2COOH;
- R2 and R6 are H, OH, SH, NH2, C 1-6 alkyl, alkoxy, alkene;
- R4 and R5 are H, C 1-6 alkoxy, or alkene;
- Y is N or C, such that when Y is N R3 is nothing, and when Y is C, R3 is NO2 or another electron withdrawing group, or salts thereof.
A method for treating or preventing albuminuria comprising administering to a mammal having an elevated blood sugar level an amount effective to prevent albuminuria of a compound of the general formula:
- wherein R1 is CH2NH2, CH2SH, COOH, CH2CH2NH2, CH2CH2SH, or CH2COOH;
- R2 and R6 are H, OH, SH, NH2, C 1-6 alkyl, alkoxy or alkene;
- R4 and R5 are H, C 1-6 alkyl, alkoxy or alkene;
- Y is N or C, such that when Y is N R3 is nothing, and when Y is C, R3 is NO2 or another electron withdrawing group, or salts thereof.
A method for treating or preventing impaired glomerular clearance comprising administering to a mammal having an elevated blood sugar level an amount effective to prevent impaired glomerular clearance of a compound of the general formula:
- wherein R1 is CH2NH2, CH2SH, COOH, CH2CH2NH2, CH2CH2SH, or CH2COOH;
- R2 and R6 are H, OH, SH, NH2, C 1-6 alkyl, alkoxy or alkene;
- R4 and R5 are H, C 1-6 aklyl, alkoxy, or alkene;
- Y is N or C, such that when Y is N R3 is nothing, and when Y is C, R3 is NO2 or another electron withdrawing group, or salts thereof.
A method for treating or preventing impaired creatinine clearance comprising administering to a mammal having an elevated blood sugar level an amount effective to prevent impaired creatinine clearance of a compound of the general formula:
- wherein R1 is CH2NH2, CH2SH, COOH, CH2CH2, NH2CH2CH2SH, or CH2COOH;
- R2 and R6 are H, OH, SH, NH2, C 1-6 alkyl, alkoxy or alkene;
- R4 and R5 are H, C 1-6 aklyl, alkoxy or alkene;
- Y is N or C, such that when Y is N R3 is nothing, and when Y is C, R3 is NO2 or another electron withdrawing group, or salts thereof.
Dependencies are inferred from the claim text.