Dimeric compounds
AssigneeThe Hong Kong University of Science and Technology
InventorsPaul R. Carlier, Yifan Han, Yuan-Ping Pang, Da-Ming Du
Life of this patent
Estimating the term…
Abstract
The invention relates to dimeric compounds comprising two 5-amino-5,6,7,8-tetrahydroquinoline fragments joined together by a divalent linking group, processes for their preparation, intermediates for their preparation, pharmaceutical compositions containing such dimeric compounds and the use of such compounds as cholinesterase inhibitors and in the treatment of neurodegenerative diseases, such as Alzheimer's Disease and myasthenia gravis.
Claims56
A dimeric compound comprising two fragments, which may be the same or different, joined together by a divalent linking group, each fragment having a nucleus of the general formula
- which may be substituted or unsubstituted, in which Q represents the number of carbon atoms necessary to form a 5,6 or 7-membered ring;
- R1 represents a hydrogen atom or an optionally substituted alkyl group;
- —W—X— represents a group —N(R2)—C(O)— or —N═C(OR3)—, where R2 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aralkyl group, and R3 represents a hydrogen atom or an optionally substituted alkyl or aralkyl group;
- or a salt thereof.
Dependencies are inferred from the claim text.