Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives

A compound of the formula:

• or the pharmaceutically acceptable salts thereof wherein:
• Ar is phenyl, 1- or 2-napthyl, 2-, 3-, or 4-pyridyl, 2-, 4-, or 5-pyrimidinyl optionally mono-, di-, or tri-substituted halogen, trifluoromethyl, hydroxy, amino, carboxamido, C1-C6 alkyl, or C1-C6 alkoxy, with the proviso that at least one of the positions ortho or para to the point of attachment of Ar to the tricyclic ring system is substituted;
• R1 is hydrogen, halogen, trifluoromethyl, C1-C6 alkyl, or (C1-C6 alkyl)-G1—R2 where G1 is oxygen or sulfur and R2 is hydrogen or C1-C6 alkyl;
• R3 is hydrogen or C1-C6 alkyl;
• m is 0, 1, or 2;
• X is
• wherein
• V1 and V2 are CH2, CO, CS, SO2 or CH(C1-C6 alkyl), with the proviso that both V1 and V2 cannot both be CO, CS or SO2;
• Y1 and Y2 independently represent a bond or C1-C6 alkylene;
• A1 is NR4R5 wherein R4 and R5 are independently
• hydrogen or a C1-C6 alkyl group where, when at least one of R4 or R5 is C1-C6 alkyl and Y1 is C1-C6 alkylene, said R4 or R5 C1-C6 alkyl together with a carbon atom in Y1 optionally forms a heterocycloalkyl group with Y1,
• acetyl or sulfonyl with the proviso that R4 and R5 cannot both be acetyl or sulfonyl;
• or
• NR4R5 represents a C3-C6 heterocycloalkyl or a group of the formula:
• wherein
• e and f are independently 1, 2, or 3 and the sum of e and f is at least 3;
• and
• G2 is
• oxygen;
• NR6 wherein R6 is hydrogen, C1-C6 alkyl, or
• CH(C0-C6 alkylene)-G3—R7 wherein G3 is CONH, CONH(C1-C6 alkyl), NH, or NH(C1-C6 alkyl) and R7 is hydrogen or C1-C6 alkyl;
• or
• CONH2, or CO(N(C1-C6 alkyl)R8) wherein R8 is hydrogen or C1-C6 alkyl;
• A2 is hydrogen, C1-C6 alkyl, (C1-C6 alkylene)-G4—R9 wherein G4 is oxygen or sulfur and R9 is hydrogen, trifluoromethyl or C1-C6 alkyl;
• wherein
• heteroaryl is 1-, 2- or 4-imidazolyl, 2-, 4-, or 5-oxazolyl, 1-, 3- or 4-pyrazolyl, 1-, 3- or 4-triazolyl, 2-pyrazinyl, or 1-, 2- or 5-tetrazolyl, each of which is optionally mono- or disubstituted with halogen, trifluoromethyl, amino, C1-C6 alkyl, C1-C6 alkoxy, with the proviso that tetrazolyl can have at most one substituent;
• Z1 is C1-C6 alkylene;
• and
• V2, Y2 and A2 are as defined above;
• or
• (iii) a nitrogen heterocycle of the formula:
• wherein the N-ring represents triazolyl, tetrazolyl, imidazolyl, or pyrazolyl, each of which is optionally substituted with amino, trifluoromethyl, carboxamido, or (C1-C6 alkylene)-G6—R12 wherein G6 is NH, or NH(C1-C6 alkyl) and R12 is hydrogen or C1-C6 alkyl.