Advanced gylcation end-product intermediaries and post-Amadori inhibition
AssigneeUniversity of Kansas Medical Center
InventorsBilly G. Hudson, Parvin Todd, Raja Gabriel Khalifah, Aaron Ashley Booth
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Abstract
The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions.
Claims4
A method for preventing proteinuria or albuminuria comprising administering to a mammal having an elevated blood sugar level an effective amount of pyridoxamine to prevent proteinuria or albuminuria.
A method for treating proteinuria or albuminuria comprising administering to a mammal having an elevated blood sugar level an effective amount of pyridoxamine to treat proteinuria or albuminuria.
A method for preventing impaired glomerular clearance or creatinine clearance comprising administering to a mammal having an elevated blood sugar level an effective amount of pyridoxamine to prevent impaired glomerular clearance.
A method for treating impaired glomerular clearance or creatinine clearance comprising administering to a mammal having an elevated blood sugar level an effective amount of pyridoxamine to treat impaired glomerular clearance or creatinine clearance.
Dependencies are inferred from the claim text.