Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof

A compound of formula (I):

• wherein
• A represents CH2 or CO,
• B represents a group —(CH2)k—, wherein k is an integer of 1-4, or —(CH2)m—CO—, wherein m is an integer of 0-3,
• X and Y are different from each other and represent N or CH,
• W represents a group represented by formula (a):
• wherein R2 and R3 represent independently a hydrogen atom or C1-6 alkyl, R4 represents C1-10 alkyl, C2-10 alkenyl, C2-5 alkynyl, aryl, or C3-8 cycloalkyl, or
• a group represented by formula (b):
• wherein R5 represents a hydrogen atom, C1-6 alkyl or C6-8 aralkyl, and R6 and R7 independently represent a hydrogen atom or C1-6, alkyl, or
• a group represented by formula (c):
• wherein R8, R9, R10 and R11 independently represent a hydrogen atom, C1-6 alkyl or C6-8 aralkyl, R12 and R13 independently represent a hydrogen atom or C1-6 alkyl,
• Z represents a group (II) or (III):
• wherein
• n is an integer of 1-3,
• D represents a group —V—(CH2)p—COOR, wherein V represents —O— or a bond, p is an integer of 1-4, R represents a hydrogen atom, C1-8 alkyl which may be substituted by a halogen atom, C5-8 cycloalkyl, benzyl, a five- to eight-membered saturated cycloalkyl group containing an oxygen or sulfur atom, 1,3-bis(C1-6alkoxy)propan-2-yl, 1,3-bis(C1-6alkylthio)propan-2-yl, C1-6alkyl-(OCH2CH2)q— wherein q is an integer of 1-3, C1-6alkyl-(SCH2CH2)r— wherein r is an integer of 1-3, R′R″NCO—(CH2)s— wherein s is an integer of 1-3, and R′ and R″ independently represent a hydrogen atom or C1-6 alkyl, or an ester moiety which may be removed under physiological conditions,
• R1 represents a hydrogen atom or C1-6 alkyl which may be substituted by carboxyl, lower alkoxy, carbamoyl, or phenyl,
• or a pharmaceutically acceptable salt or solvate thereof.