Cyclic diamine compound with 5-membered ring groups

A pharmaceutical composition comprising, as an active ingredient, a compound of formula (1):

• wherein A is a single bond, C≡C, CONH or NHCO;
• W is a carbon atom or a nitrogen atom;
• X is CH, a nitrogen atom, an oxygen atom or a sulfur atom;
• Y is CH, CHR1, in which R1 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group, a nitrogen atom, an oxygen atom, a sulfur atom or NR2, in which R2 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group;
• Z is a nitrogen atom, an oxygen atom, a sulfur atom, CH or NR3, in which R3 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group;
• m is 1 or 2;
• and n is a number of 1 to 5, with the proviso that one or two of W, X, Y and Z are heteroatoms;
• an acid-addition salt thereof, or a hydrate thereof, and a pharmaceutically acceptable carrier.

A method for treating a disease caused by cell adhesion and/or cell infiltration, wherein said disease is allergy, asthma, inflammation, rheumatism, and arteriosclerosis, which comprises administering to a patient in need thereof an effective amount of a compound of formula (1):

• wherein A is a single bond, C≡C, CONH or NHCO;
• W is a carbon atom or a nitrogen atom;
• X is CH, a nitrogen atom, an oxygen atom or a sulfur atom;
• Y is CH, CHR1, in which R1 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group, a nitrogen atom, an oxygen atom, a sulfur atom or NR2, in which R2 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group;
• Z is a nitrogen atom, an oxygen atom, a sulfur atom, CH or NR3, in which R3 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group;
• m is 1 or 2;
• and n is a number of 1 to 5, with the proviso that one or two of W, X, Y and Z are heteroatoms;
• an acid-addition salt thereof, or a hydrate thereof.