Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
AssigneeSchering Corporation
InventorJanice K. Albrecht
Life of this patent
Estimating the term…
Abstract
Methods for treating an antiviral treatment naive patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving administering a therapeutically effective amount of a combination therapy of ribavirin and interferon-alpha for a time period of from 20 up to 50 weeks are disclosed.
Claims19
A method of treating antiviral treatment naive patients having chronic hepatitis C (“HCV”) infection comprising identifying antiviral treatment naive patients having HCV genotype 1 and an initial viral load of greater than 2 million copies/ mL of serum HCV-RNA as measured by HCV-RNA/ quantitative Polymerase Chain Reaction (“qPCR”) and then administering to said antiviral treatment naïve patients a therapeutically effective amount of ribavirin and a therapeutically effective amount of interferon-alpha for a time period of about 40 to about 50 weeks and identifying antiviral treatment naive patients having an HCV genotype 1 and an initial viral load of less than or equal to 2 million copies/ mL of serum HCV-RNA as measured by HCV-RNA/ quantitative Polymerase Chain Reaction (“qPCR”) and then administering to said antiviral treatment naive patients a therapeutically effective amount of ribavirin and a therapeutically effective amount of interferon-alpha for a time period of about 20 to about 24 weeks.
A method of treating antiviral treatment naïve patients having chronic hepatitis C (“HCV”) infection comprising identifying antiviral treatment naive patients having an HCV genotype 1 and an initial viral load of greater than 2 million copies/ ML of serum HCV-RNA as measured by HCV-RNA/ quantitative Polymerase Chain Reaction (“qPCR”) and then administering to said antiviral treatment naive patients a therapeutically effective amount of ribavirin and a therapeutically effective amount of interferon-alpha for a time period of about 48 weeks and identifying antiviral treatment naive patients having an HCV genotype 1 and an initial viral load of less than or equal to 2 million copies/mL of serum HCV-RNA as measured by HCV-RNA/ quantitative Polymerase Chain Reaction (“qPCR”) and then administering to said antiviral treatment naive patients therapeutically effective amount of ribavirin and a therapeutically effective amount of interferon-alpha for a time period of at least about 24 weeks and up to about 48 weeks.
A method of treating antiviral treatment naive patients having chronic hepatitis C (“HCV”) infection comprising identifying antiviral treatment naive patients having an HCV genotype 2 or 3 and administering to said antiviral treatment naive patients a therapeutically effective amount of ribavirin and a therapeutically effective amount of interferon-alpha for a time period of at least about 20 weeks to about 24 weeks.
A method of treating antiviral treatment naive patients having chronic hepatitis C (“HCV”) infection comprising identifying antiviral treatment naive patients having an HCV genotype 2 or 3 and administering to said antiviral treatment naive patients a therapeutically effective amount of ribavirin and a therapeutically effective amount of interferon-alpha for a time period of at least about 24 weeks.
Dependencies are inferred from the claim text.