Anticancer compounds and methods
AssigneeThe Regents of the University of Michigan
InventorDonna Livant
Life of this patent
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Abstract
The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human cells, is performed with invasion-inducing agents. Additionally, anti-cancer chemotherapeutics are described. Specifically, chemotherapeutic agents which have anti-metastatic and anti-growth properties are described including non-peptide compositions of matter.
Claims10
A composition of matter comprising a cyclic PHSCN-containing (SEQ ID NO:86) peptide which inhibits the tumor invasion-promoting activity of a peptide comprising the amino acid sequence PHSRN (SEQ ID NO:1).
A composition of matter comprising a cyclic peptide which inhibits the tumor invasion-promoting activity of a peptide comprising the amino acid sequence PHSRN (SEQ ID NO:1), wherein said cyclic peptide has an amino acid sequence comprising a sequence selected from the group consisting of CHSRN (SEQ ID NO:87), PCSRN (SEQ ID NO:88), PHCRN (SEQ ID NO:89), PHSRC (SEQ ID NO:90).
Dependencies are inferred from the claim text.