Compounds and methods for modulating adhesion molecule function
AssigneeAdherex Technologies, Inc.
InventorsPatrick Doherty, Orest W. Blaschuk, Barbara J. Gour
Life of this patent
Estimating the term…
Abstract
Modulating agents and methods for enhancing or inhibiting cadherin-mediated functions are provided. The modulating agents comprise at least an HAV binding motif, an analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a motif. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
Claims3
A cell adhesion modulating agent consisting of a cyclic peptide selected from the group consisting of:
- Wherein X1 and X2 are absent, Z1 and Z2 are absent, and Y1 and Y2 are cysteine residues.
A cell adhesion modulating agent consisting of a cyclic peptide selected from the group consisting of PVNGQ (SEQ ID NO:5 1), PVSGR (SEQ ID NO:53), KIDPV (SEQ ID NO:54), KIDPVN (SEQ ID NO:55), IDPVN (SEQ ID NO:56), INPIS (SEQ ID NO:57), CPVNGQC (SEQ ID NO:58), CPISGQC (SEQ ID NO:59), CPVSGRC (SEQ ID NO:60), CKIDPVNC (SEQ ID NO:61), CIDPVNC (SEQ ID NO:62), CINPISC (SEQ ID NO:63), CKIDPVC (SEQ ID NO:85), CINPC (SEQ ID NO:86) and CINPIC (SEQ ID NO:87).
Dependencies are inferred from the claim text.