Composition and method for allogeneic mononuclear cell immunotherapy
AssigneeThomas Jefferson University
InventorsJ. Bruce Smith, John G. Fort
Life of this patent
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Abstract
A method of treating autoimmune diseases is provided which involves administering an effective amount of allogeneic mononuclear cells or a molecule derived from these cells to an individual suffering from an autoimmune disease. Also provided are compositions for the treatment of autoimmune diseases.
Claims4
A method of identifying patient donor pairs having an increased probablility of effective alloimmunozation treatment of autoimmune disease in a selected patient, comprising the steps of:
- providing a patient and a donor;
- measuring differences between selected histocompatibility antigens expressed on the MNC of the donor and the patient;
- and
- identifying a patient donor pair based on the measured differences between selected histocompatibility antigens.
A method of identifying patient donor pairs having an increased probablility of effective alloimmunozation treatment of autoimmune disease in a selected patient, comprising the steps of:
- providing a patient and a donor;
- measuring in vitro immune responses of patient lymphocytes to donor MNC or MNC membrane extracts;
- and
- identifying a patient donor pair based on the measured in vitro immune responses of patient lymphocytes.
A method of identifying patient donor pairs having an increased probablility of effective alloimmunozation treatment of autoimmune disease in a selected patient, comprising the steps of:
- providing a patient and a donor;
- determining the presence of patient antibodies directed against donor MNC membrane extracts, either before immunization or following the first treatment of the patient;
- and
- identifying a patient donor pair based on the presence of said antibodies.
Dependencies are inferred from the claim text.