Loading patent…
AssigneeMayo Foundation for Medical Education and Research
InventorsElliott Richelson, Beth Marie Tyler, Daniel J. McCormick, Bernadette Marie Cusack, Clark V. Hoshall, Christopher Lee Douglas, Karen Jansen
Estimating the term…
The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.
A method of treating living cells, said method comprising extracellularly administering to said cells a polyamide nucleic acid oligomer containing neutral amide backbone linkages which is complementary to a target nucleic acid, under conditions wherein a biological response associated with said target in a sequence specific manner, said administration being in vivo.
A method of treating a mammal, said method comprising:
Dependencies are inferred from the claim text.