GRB2 associating polypeptides and nucleic acids encoding therefor
AssigneesThe Regents of the University of California, Washington University
InventorsDavid A. Pot, Lewis T. Williams, Anne Bennett Jefferson, Philip W. Majerus
Life of this patent
Estimating the term…
Abstract
The present invention generally relates to novel GRB2 associating proteins and nucleic acids which encode these protein. In particular, these novel proteins possess inositol polyphosphate 5-phosphatase and phosphatidylinositol 5-phosphatase activities, important in growth factor mediated signal transduction. As such, the proteins, nucleic acids encoding the proteins, cells capable of expressing these nucleic acids and antibodies specific for these proteins will find a variety of uses in a variety of screening, therapeutic and other applications.
Claims6
An isolated nucleic acid encoding a polypeptide having an amino acid sequence shown in FIG. 10 (SEQ ID NO:2), or a catalytically active fragment of an amino acid sequence shown in FIG. 10 (SEQ ID NO:2), wherein said fragment comprises an inositol polyphosphate 5-phosphatase activity such that said fragment hydrolyzes a 5-phosphate from Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3, but not Ins(1,4,5)P3 or PtdIns(4,5)P2.
Dependencies are inferred from the claim text.