DNA encoding a novel human inhibitor-of-apoptosis protein
AssigneeSchering Corporation
InventorsGang Deng, Jiing-Huey Lin, Michael John Morser
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel human inhibitor-of-apoptosis polypeptides, designated HIAP3, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to methods for utilizing the polynucleotides and polypeptides in research, diagnosis, and therapeutic applications.
Claims17
An isolated polynucleotide comprising a polynucleotide sequence having at least a 95% identity over its entire length to a nucleic acid selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide of the amino acid sequence set forth in FIG. 2 (SEQ ID NO:
- 2);
- (b) a polynucleotide encoding a polypeptide of amino acid 88 to amino acid 289 as set forth in FIG. 2 (SEQ ID NO:
- 2);
- (c) a polynucleotide encoding a polypeptide of amino acid 88 to amino acid 155 as set forth in FIG. 2 (SEQ ID NO:
- 2);
- and
- (d) a polynucleotide which is fully complementary to the polynucleotide of (a), (b), or (c);
- and wherein said polypeptides (a)-(d) contain a BIR domain and wherein said polypeptides are apoptosis inhibitors.
An isolated polynucleotide wherein the polynucleotide encodes a polypeptide comprising amino acids 1 to 298 as set forth in FIG. 2 (SEQ ID NO:
- 2), wherein said polypcptide is an apoptosis inhibitor.
Dependencies are inferred from the claim text.