Ustilipides, method for the production and the use thereof
AssigneeAventis Pharma Deutschland GmbH
InventorsLaszló Vértesy, Michael Kurz, Gerhard Noelken, Joachim Wink
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Abstract
New active agents (ustilipides) formed by the microorganism Ustilago maydis, FH 2634, DSM 11494 during fermentation. The invention also relates to a method for the production of said ustilipides and to their use as medicaments in the treatment of schizophrenia or diseases caused by dopamine metabolic dysfunction. The invention further relates to medicaments containing ustilipides and to the microorganism Ustilago maydis, FH 2634, DSM 11494.
Claims26
A compound of the formula I
- where
- R2, R3 and R4 are, independently of one another, acyl radicals with 2-25 carbon atoms, which are unsubstituted or are substituted, independently of one another, by 1, 2 or 3 (C6-C12)-aryl radicals;
- and
- R is hydrogen or a radical defined under R2, R3 and R4,
- where in the case where R is hydrogen, then R2 is an acyl radical with 3-25 carbon atoms, which is unsubstituted or substituted by 1, 2 or 3 (C6-C12)-aryl radicals;
- or a physiologically tolerated salt thereof.
A compound of the formula (II)
- where n is 11;
- or a physiologically tolerated salt thereof.
A compound of the formula (III)
- where n is 11;
- or a physiologically tolerated salts thereof.
A compound of the formula (IV)
- where n is 11;
- or a physiologically tolerated salt thereof.
The isolated microorganism Ustilago maydis DSM 11494.
Dependencies are inferred from the claim text.