Methods for detection of promoter polymorphism in a UGT gene promoter
AssigneeArch Development Corporation
InventorsAnna Di Rienzo, Lalitha Iyer, Mark J. Ratain
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Abstract
The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
Claims26
A method for detecting polymorphisms in a uridine diphosphate glucuronosyl transferase (UGT) gene promoter comprising determining the presence of eight (TA) repeats in said promoter.
A method for detecting polymorphisms in a uridine diphosphate glucuronosyltransferase I (UGT1A1) gene promoter comprising determining the presence of eight (TA) repeats in said promoter.
A method for screening individuals for variation in glucuronidation activity comprising detecting polymorphisms in a uridine diphosphate glucuronosyltransferase (UGT) gene promoter comprising determining the presence of eight (TA) repeats in said promoter.
A method for screening individuals for variation in glucuronidation activity comprising detecting polymorphisms in a uridine diphosphate glucuronosyltransferase I (UGT1A1) gene promoter, the method comprising determining the presence of eight (TA) repeats in said promoter.
Dependencies are inferred from the claim text.