Methods and means for inducing apoptosis by interfering with Bip-like proteins
AssigneeLeadd B.V.
InventorsMathieu Hubertus Maria Noteborn, Astrid Adriana Anna Maria Danen-Van Oorschot
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Abstract
The invention relates to activation of apoptosis by means of interference of the function of Bip-like compounds. Also the invention relates to anti-tumor therapies with compounds, which negatively interfere with Bip-like compounds leading to induction of apoptosis, resulting in the elimination of tumor cells. Also the invention relates to therapies for diseases related to aberrant apoptosis induction, such as auto-immune diseases. Also the invention describes the diagnosis of cells, which are susceptible to apoptin or apoptin-like induced apoptosis.
Claims6
A method for inducing apoptosis in a cell that expresses Bip/GRP78, said method comprising:
- providing said cell with apoptin which interferes with Bip/GRP78-mediated apoptosis inhibiting activity.
A method for inducing apoptosis in a cell, said method comprising:
- providing said cell with apoptin and a second protein wherein said second protein comprises Bip/GRP78-mediated apoptosis inhibiting activity and wherein said second protein associates with apoptin.
Dependencies are inferred from the claim text.