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AssigneesThe Brigham and Women's Hospital, Inc., NitroMed, Inc.
InventorsJonathan S. Stamler, Joseph Loscalzo, John D. Folts
Estimating the term…
A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; can be coated per se on a surface of the medical device; can be directly or indirectly bound to reactive sites on a surface of the medical device; or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue.
A method for treating a damaged vascular surface comprising administering at least one nitric oxide adduct to the damaged vascular surface, wherein the damaged vascular surface is the interior surface of a blood vessel in which damage to the endothelium or subendothelium, narrowing or stenosis of the vessel has occurred, and wherein the nitric oxide adduct is a sodium nitroprusside, a nitrosothiol, a nitrate, a nitrite, a nitrosated amino acid, a iron-nitrosyl compound, a sydnonimine, or a furoxan.
A method for passivating a damaged portion of a vascular surface thereby rendering the surface non-reactive comprising applying to the damaged vascular surface at least one nitric oxide adduct, wherein the damaged vascular surface is the interior surface of a blood vessel in which damage to the endothelium or subendothelium, narrowing or stenosis of the vessel has occurred, and wherein the nitric oxide adduct is a sodium nitroprusside, a nitrosothiol, a nitrate, a nitrite, a nitrosated amino acid, a iron-nitrosyl compound, a sydnonimine, or a furoxan.
A method for inhibiting cyclic reductions in blood flow through a portion of a vascular lumen, wherein at least a portion of the vascular lumen has a damaged vascular surface, comprising applying to the damaged vascular surface an amount of at least one nitric oxide adduct effective to inhibit cyclic reduction in blood flow through said portion of said vascular lumen, wherein the damaged vascular surface is the interior surface of a blood vessel in which damage to the endothelium or subendothelium, narrowing or stenosis of the vessel has occurred, and wherein the nitric oxide adduct is a sodium nitroprusside, a nitrosothiol, a nitrate, a nitrite, a nitrosated amino acid, a iron-nitrosyl compound, a sydnonimine, or a furoxan.
Dependencies are inferred from the claim text.