Multifunctional nanodevice platform
AssigneeThe Regents of the University of Michigan
InventorsJames R. Baker, Jr., Donald A. Tomalia
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Abstract
The present invention relates to novel therapeutic and diagnostic arrays. More particularly, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems generally comprise two or more separate components for targeting, imaging, sensing, and/or triggering release of a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
Claims34
A composition comprising a dendrimer complex, said dendrimer complex comprising covalently linked first and second dendrimers, said first dendrimer comprising a first agent and said second dendrimer comprising a second agent, wherein said first dendrimer is different from said second dendrimer, and wherein said first agent is different than said second agent.
The composition of claim 21, wherein said biological imaging agent comprises a radioactive label selected from the group consisting of 14C, 36Cl, 57Co, 58Co, 51Cr, 125I, 131I, 111ln, 152Eu, 59Fe, 67Ga, 32P, 186Re, 35S, 75Se, Tc-99m, and 175Yb.
A method of treating a cell comprising:
- a) providing:
- i) an in vitro or ex vivo cell;
- and
- ii) a composition comprising a dendrimer complex, said dendrimer complex comprising covalently linked first and second dendrimers, said first dendrimer comprising a first agent and said second dendrimer comprising a second agent, wherein said first dendrimer is different from said second dendrimer, and wherein said first agent is different than said second agent;
- and
- b) exposing said cell to said composition.
Dependencies are inferred from the claim text.