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US 6,471,943 B1Granted
Formulation and method for treating neoplasms by inhalation
AssigneeBattelle Pulmonary Therapeutics, Inc.
InventorsMichael E. Placke, Anthony R. Imondi
Life of this patent
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Abstract
A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.
Claims81
A method for treating a patient having a neoplasm comprising:
- administering a pharmaceutically safe and effective amount of non-encapsulated doxorubicin to said patient by inhalation, wherein said safe and effective amount provides an animal dose of about 2 to 90 mg/m2 or a human dose of about 3 to 130 mg/m2, wherein both doses are based on body surface area, and wherein said doxorubicin is inhaled in an aerosol.
A method for treating a human patient having a neoplasm of the respiratory tract comprising:
- administering to said patient by inhalation, a formulation comprising non-encapsulated doxorubicin in a pharmaceutically acceptable carrier at a safe and effective dose, wherein said administering of said safe and effective dose provides a dose of about 3 to 130 mg/m2, wherein said dose is based on body surface area, said doxorubicin is inhaled in an aerosol having a particle size of 0.1 to 10 μm and approximately one half of said dose is deposited within the respiratory tract;
- and said effective dose stops growth of, reduces, or eliminates said neoplasm.
A method for treating a human patient having a pulmonary neoplasm comprising:
- administering to said patient by inhalation, a formulation comprising non-encapsulated doxorubicin in a pharmaceutically acceptable carrier at a safe and effective dose, wherein said administering of said safe and effective dose provides a dose of about 3 to 130 mg/m2, wherein said dose is based on body surface area, said doxorubicin is inhaled in an aerosol having a particle size from about 1.0 to 5.0 μm with a geometric standard deviation of less than about 2.0;
- and said effective dose stops growth of, reduces, or eliminates said neoplasm.
A method for treating a patient for a neoplasm comprising:
- (1) administering a safe and effective amount of non-encapsulated doxorubicin to said patient by inhalation, wherein said safe and effective amount provides an animal dose of about 2 to 90 mg/m2 or a human dose of about 3 to 130 mg/m2, wherein both doses are based on body surface area, and wherein said doxorubicin is inhaled in an aerosol;
- and
- (2) administering an effective amount of non-encapsulated doxorubicin and/or a different antineoplastic drug to said patient by isolated organ perfusion;
- and
- wherein said effective amounts in steps (1) and (2) stop the growth of, reduce, or eliminate said neoplasm.
2 more elements
A method for treating a patient for a neoplasm consisting of:
- (1) administering a safe and effective amount of non-encapsulated doxorubicin to said patient by inhalation, wherein said safe and effective amount provides an animal dose of about 2 to 90 mg/m2 or a human dose of about 3 to 130 mg/m2, wherein both doses are based on body surface area, and wherein said doxorubicin is inhaled in an aerosol;
- and
- (2) administering a safe and effective amount of doxorubicin and/or a different antineoplastic drug to said patient parenterally;
- and
- wherein said effective amounts in steps (1) and (2) stop the growth of, reduce, or eliminate said neoplasm.
2 more elements
A method for treating a patient for a neoplasm consisting of:
- (1) administering a safe and effective amount of non-encapsulated doxorubicin to said patient by inhalation, wherein said safe and effective amount provides an animal dose of about 2 to 90 mg/m2 or a human dose of about 3 to 130 mg/m2, wherein both doses are based on body surface area, and wherein said doxorubicin is inhaled in an aerosol;
- and
- (2) administering a safe and effective amount of doxorubicin and/or a different antineoplastic drug to said patient by isolated organ perfusion;
- and
- wherein said effective amounts in steps (1) and (2) stop the growth of, reduce, or eliminate said neoplasm.
2 more elements
A method for treating a patient for a neoplasm comprising:
- (1) administering a safe and effective amount of non-encapsulated doxorubicin to said patient by inhalation, wherein said safe and effective amount provides an animal dose of about 2 to 90 mg/m2 or a human dose of about 3 to 130 mg/m2, wherein both doses are based on body surface area, and wherein said doxorubicin is inhaled in an aerosol;
- and
- (2) administering an effective amount of non-encapsulated doxorubicin and/or a different antineoplastic drug to said patient by isolated organ perfusion;
- and wherein said effective amounts in steps (1) and (2) stop the growth of, reduce, or eliminate said neoplasm.
1 more element
A method for treating a patient having a neoplasm comprising:
- administering to said patient by inhalation, a formulation comprising non-encapsulated doxorubicin in a pharmaceutically acceptable carrier at a safe and effective dose, wherein said administering of safe and effective dose provides an animal dose of about 2 to 90 mg/m2 or a human dose of about 3 to 130 mg/m2, wherein both doses are based on body surface area, said doxorubicin is inhaled in an aerosol;
- and
- wherein said effective dose stops growth of, reduces, or eliminates said neoplasm.
A method for treating a patient for a neoplasm comprising:
- (1) administering a safe and effective amount of non-encapsulated doxorubicin to said patient by inhalation, wherein said safe and effective amount provides an animal dose of about 2 to 90 mg/m2 or a human dose of about 3 to 130 mg/m2, wherein both doses are based on body surface area, and wherein said doxorubicin is inhaled in an aerosol;
- and
- (2) administering a safe and effective amount of doxorubicin and/or a different antineoplastic drug to said patient parenterally;
- and
- wherein said effective amounts in steps (1) and (2) stop the growth of, reduce, or eliminate said neoplasm.
2 more elements
A method for treating a patient for a neoplasm comprising:
- (1) administering a safe and effective amount of non-encapsulated doxorubicin to said patient by inhalation, wherein said safe and effective amount provides an animal dose of about 2 to 90 mg/m2 or a human dose of about 3 to 130 mg/m2, wherein both doses are based on body surface area, and wherein said doxorubicin is inhaled in an aerosol;
- and
- (2) administering a safe and effective amount of doxorubicin and/or a different antineoplastic drug to said patient by isolated organ perfusion;
- and
- wherein said effective amounts in steps (1) and (2) stop the growth of, reduce, or eliminate said neoplasm.
2 more elements
Dependencies are inferred from the claim text.