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US 6,471,855 B1Granted
Cassette with integral separation device
AssigneeBaxter International Inc.
InventorsSanjay V. Odak, Mark R. Vandlik, Tom Westberg
Life of this patent
Estimating the term…
Abstract
A pneumatic pump manifold disposable system, configured as a cassette, is used for the purpose of red cell and plasma apheresis. The cassette integrates a separation device, manifold system, macro-aggregate filter, and five pumping chambers for the purpose of separating plasma and red cells from the whole blood. The cassette system, with the separation device directly attached without tubing, simplifies the loading of the disposable set into the hardware, and reduces the manufacturing complexity of the set. The system allows for plasma, plasma and red cells, or just red cells to be stored in long term storage containers after a procedure.
Claims41
A disposable module adapted for cooperative mounting on a reusable module for processing a suspension comprising blood or blood components, said disposable module comprising:
- an integral flow control cassette and separator;
- said separator comprising a rotor rotatably mounted therein;
- said flow control cassette comprising a rigid base and including a suspension inlet for communicating with a suspension source and defining a first closed flow path in said base for direct fluid contact, said first flow path communicating between said suspension inlet and said separator;
- said separator and said base being connected to provide a unitary module adapted for mounting onto said reusable module;
- said separator including an inlet communicating with said first flow path of said cassette to receive the suspension into said separator;
- said separator including an outlet for a separated portion of said suspension;
- and
- said cassette defining a second closed flow path in said base for direct fluid contact communicating with said separator outlet.
5 more elements
A suspension processing system, comprising:
- a disposable module having an integral flow control cassette and separator;
- said separator comprising a rotor rotatably mounted therewithin;
- said flow control cassette comprising a rigid base and including a suspension inlet for communicating with a suspension source and defining a first closed flow path in said base for direct fluid contact communicating between said suspension inlet and said separator;
- said separator and said base being connected to provide a unitary module;
- said separator including an inlet communicating with said inlet flow path of said cassette to receive the suspension into said separator;
- said separator including an outlet for a separated portion of said suspension;
- said cassette defining a second closed flow path in said base for direct fluid contact communicating with said separator outlet;
- and
- a reusable module for receiving said disposable module, said reusable module having a plurality of actuators cooperative with said disposable module for controlling flow through said flow paths for the processing of said suspension.
6 more elements
A disposable blood separation set for installation on an actuator device having a plurality of pressure actuators responsive to a control program, the separation set comprising:
- a cassette including a rigid base and defining in said rigid base pre-formed pressure actuated pump stations, pre-formed closed fluid flow paths for direct fluid contact and pre-formed pressure actuated valve stations interconnecting two or more fluid flow paths;
- a fluid separation device integral with said cassette and in communication with said fluid paths, the separation device and cassette forming a unitary module adapted for installation onto said actuator device;
- and
- a plurality of cassette ports in direct communication with said flow paths to direct the flow of fluids to and from said cassette and said separation device when the pressure actuators selectively change pressure to said valve and pump stations in response to a control program.
1 more element
A fluid processing system, comprising:
- a disposable cassette including a rigid base and defining in said rigid base pre-formed pressure actuated pump stations, pre-formed closed fluid flow paths for direct fluid contact and pre-formed pressure actuated valve stations inter-connecting two or more fluid flow paths;
- a fluid separation device integral with said cassette and in communication with said fluid paths, the separation device and cassette forming a unitary module;
- an actuator device for receiving said cassette, said actuator device having a plurality of pressure actuators responsive to a control program;
- and
- a plurality of cassette ports in communication with said flow paths to direct the flow of fluids to and from said cassette and said separation device when said pressure actuators selectively apply pressure force to said valve and pump stations in response to said control program.
2 more elements
A disposable blood separation set for installation on an actuator device having a plurality of pressure actuators responsive to a control program, the separation set comprising:
- a cassette including a rigid base and defining pre-formed pressure actuated pump stations, pre-formed closed fluid flow paths and pre-formed pressure actuated valve stations;
- a fluid separation device integral with said cassette and in communication with said paths, said separation device having a first generally cylindrical member having a hollow interior and an inner surface, a second generally cylindrical member positioned within said first member, said second member having an outer surface spaced apart from said inner surface of said first member to define a fluid-receiving gap therebetween, one of said paths communicating with said gap, a micro-porous filter membrane disposed on one of said surfaces for passing a filtrate therethrough, one of said paths communicating with said filtrate passing through said membrane, rotating means coupled to one of said members for driving the rotating member at a rate selected to establish annular vortices within said gap, the separation device and cassette forming a unitary module adapted for installation onto said actuator device;
- and
- a plurality of cassette ports in communicable with said flow paths to convey the flow of fluids to and from said cassette and said separation device when said pressure actuators selectively apply pressure force to said valve and pump stations in response to the control program.
1 more element
A fluid processing system, comprising:
- a disposable cassette including a rigid base and defining pre-formed pressure actuated pump stations, pre-formed fluid flow paths and pre-formed pressure actuated valve stations;
- a fluid separation device integral with said cassette and in communication with said paths, said separation device having a first generally cylindrical member having a hollow interior and an inner surface, a second generally cylindrical member positioned within said first member, said second member having an outer surface spaced apart from said inner surface of said first member to define a fluid-receiving gap therebetween, one of said paths communicating with said gap, a micro porous filter membrane disposed on one of said surfaces for passing a filtrate therethrough, one of said paths communicating with said filtrate passing through said membrane, rotating means coupled to one of said members for driving the rotating member at a rate selected to establish annular vortices within said gap, the separation device and cassette forming a rigid unitary structure;
- an actuator device for receiving said cassette, said actuator device having a plurality of pressure actuators responsive to a control program;
- and
- a plurality of cassette ports in communicable with said flow paths to convey the flow of fluids to and from said cassette and said separation device when said pressure actuators selectively apply pressure force to said valve and pump stations in response to said control program.
2 more elements
Dependencies are inferred from the claim text.