Gel compositions containing metronidazole
AssigneeDow Pharmaceutical Sciences, Inc.
InventorsYunik Chang, Gordon J. Dow, Arturo Angel
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Abstract
An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains the solubility enhancer hydroxypropyl-betacyclodextrin and may additionally contain niacinamide. Methods of manufacture and therapeutic use of the solution are disclosed.
Claims28
An aqueous solution comprising hydroxypropyl-betacyclodextrin (HPCD), niacinamide, and metronidazole.
A method for making an aqueous solution of metronidazole comprising combining hydroxypropyl-betacyclodextrin (HPCD), niacinamide, and metronidazole in water.
A method for the treatment of a dermatologic or mucosal disorder comprising topically applying an effective amount of aqueous solution of metronidazole having a concentration higher than 0.75% w/w to the site of the disorder and permitting the metronidazole to treat the disorder, wherein the solution further comprises hydroxypropyl-betacyclodextrin and niacinamide.
A kit for the topical treatment of dermatologic or mucosal disorders comprising a container and an aqueous solution of metronidazole within the container, wherein the solution further comprises hydroxypropyl-betacyclodextrin (HPBD) and niacinamide.
Dependencies are inferred from the claim text.