Controllable ion-exchange membranes
AssigneeThe Regents of the University of California
InventorsZhizhong Hou, Pieter Stroeve, Nicholas Abbott
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Abstract
Multilayered porous materials are formed by coating a porous substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel porous materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis and the like.
Claims71
A multilayered porous membrane comprising:
- (a) a porous substrate;
- (b) a metal film adhered onto said substrate;
- and
- (c) an organic layer attached to said metal film, said organic layer having a recognition moiety attached thereto,
- wherein said membrane is porous.
A multilayered porous membrane comprising:
- (a) a porous polycarbonate track-etched substrate;
- (b) a metal film adhered onto said substrate;
- and
- (c) an organic layer attached to said metal film, said organic layer having a recognition moiety attached thereto
- wherein said membrane is porous.
A multilayered porous ion exchange membrane comprising:
- (a) a porous substrate;
- (b) a metal film adhered onto said substrate;
- and
- (c) an organic layer attached to said metal film, said organic layer comprising a recognition moiety that binds or repels an ion
- wherein said membrane is porous.
A method of producing a multilayered porous membrane comprising:
- (a) contacting a porous substrate with a metal plating solution to form a porous substrate having a metal film adhered thereto;
- (b) contacting said metal coated substrate from step (a) with a solution comprising nitric acid, thereby activating said metal film;
- (c) contacting said metal coated substrate from step (b) with a plurality of organic molecules that associate with the activated metal film, thereby forming an organic layer on said particle, wherein at least a portion of said plurality of organic molecules comprise a member selected from the group consisting of recognition moieties, reactive groups, protected reactive groups and combinations thereof
- wherein said membrane is porous.
A drug delivery device comprising:
- (a) a porous substrate;
- (b) a metal film adhered onto said substrate;
- (c) an organic layer attached to said metal film, said organic layer comprising a recognition moiety;
- and
- (d) a drug moiety reversibly associated with said recognition moiety.
Dependencies are inferred from the claim text.