Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
AssigneeMassachusetts Institute of Technology
InventorsStephen L. Buchwald, Seble Wagaw, O. Geis
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Abstract
A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.
Claims20
A method for the vinylation of hydrazines, hydrazones, hydroxylamines and oximes, comprising reacting a base, a transition metal catalyst, a substrate vinyl compound comprising an activated carbon bearing a leaving group, and a hydrazine, hydrazone, hydroxylamine or oxime under conditions suitable for the transition metal catalyst to effect the formation of a carbon-heteroatom bond between the activated carbon of said substrate vinyl compound and a heteroatom of said hydrazine, hydrazone, hydroxylamine or oxime.
Dependencies are inferred from the claim text.