Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function

Abstract

The invention relates to a nucleophilic reagent which is useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function, or for the synthesis of oxysulphide-containing and fluorine-containing organic derivatives, wherein said reagent comprises: a) a fluorocarboxylic acid of formula Ew—CF2—COOH where Ew represents an electron-withdrawing atom or group, at least partially salified with an organic or inorganic cation, and b) a polar aprotic solvent; and in that the content of releasable protons carried by its various components, including their impurities, is at most equal to half the initial molar concentration of the said fluorocarboxylic acid. A synthetic process uses this reagent by heating in order to graft a substituted difluoromethyl group onto various compounds.

Dependencies are inferred from the claim text.