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AssigneesUniversity of Georgia Research Foundation, Inc., Emory University
InventorsJ. Phillip Bowen, Thomas Phillip Robinson, Tedman Ehlers, David Goldsmith, Jack Arbiser
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The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, incluidng angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
A compound according to the formula:
A pharmaceutical composition comprising an effective amount of a compound according to the formula:
A method of treating a tumor or cancer in a patient in need thereof comprising administering to said patient an effective amount of a compound according to the structure:
A method of treating an angiogenic disorder in a patient in need thereof comprising administering to said patient an effective amount of a compound according to the structure according to the structure:
Dependencies are inferred from the claim text.