Hydrophilic lubricant coatings for medical devices
AssigneeSciMed Life Systems, Inc.
InventorsLixiao Wang, Dachuan Yang, John Jianhua Chen, Yiqun Bruce Wang, Lance A. Monroe, Joel R. Munsinger
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Abstract
The present invention relates to a medical device comprising at least one tubular member having an inner surface and an outer surface. The inner surface of the tubular member is at least occasionally subjected to contact with at least one second surface. The tubular member therefore comprises a hydrophilic lubricious coating disposed on its inner surface to reduce the friction between the inner surface of the tubular member and the second surface which is caused by movement.
Claims38
A medical device comprising at least one tubular member having an inner surface and an outer surface wherein said inner surface of said tubular member is at least occasionally subjected to contact with at least one second surface, said tubular member comprising a hydrophilic coating disposed on said inner surface of said tubular member, wherein said hydrophilic coating is present to reduce the friction between the inner surface of said tubular member and said second surface caused by movement, and said inner surface of said tubular member is pretreated with a crosslinkable primer composition.
A stent deployment catheter assembly comprising:
- a. at least one tubular member for retention and release of a stent selected from the group consisting of a retractable sheath and at least one stent retaining sleeve wherein said tubular member has an inner surface and an outer surface wherein said inner surface comprises a hydrophilic, lubricious, coating;
- and
- b. a stent;
- wherein said inner surface of said tubular member is at least occasionally subjected to contact with said stent and said hydrophilic coating reduces friction between said inner surface of said tubular member and said stent.
A medical device for insertion into the body, comprising a first surface which is at least periodically subjected to contact with a second surface;
- said first surface, comprising:
- a) a crosslinkable silicone primer having substituents capable of forming hydrogen bonds;
- and
- b) a lubricious, biocompatible hydrophilic polymer;
- wherein said crosslinkable silicone primer improves retention of said hydrophilic polymer to said polymeric surface, and said hydrophilic polymer reduces friction between said first polymeric surface and said second surface.
A method of forming a lubricious hydrophilic coating on the inner surface of a tubular member comprising the steps of:
- a) coextruding a first hydrophobic polymer simultaneously with a second hydrophobic polymer wherein said first and second polymers form a tubular member having a first inner hydrophobic surface formed from said first hydrophobic polymer and a second outer hydrophobic surface formed from said second polymer;
- and
- b) converting said first inner hydrophobic surface to a lubricious hydrophilic surface.
A method of forming a lubricious hydrophilic coating on the inner surface of a tubular member comprising the steps of:
- a) coextruding a first hydrophobic polymer simultaneously with a second hydrophobic polymer wherein said first and second polymers form a tubular member having a first inner hydrophobic surface formed from said first hydrophobic polymer and a second outer hydrophobic surface formed from said second polymer;
- and
- b) converting said first inner hydrophobic surface to a lubricious hydrophilic surface.
A medical device comprising at least one tubular member having an inner surface and an outer surface wherein said inner surface of said tubular member is at least occasionally subjected to contact with at least one second surface, said tubular member comprising a hydrophilic coating disposed on said inner surface of said tubular member, wherein said hydrophilic coating is present to reduce the friction between the inner surface of said tubular member and said second surface caused by movement, and said inner surface of said tubular member is pretreated with a primer compound comprising substituents that improve the retention of said hydrophilic coating by hydrogen bonding.
Dependencies are inferred from the claim text.