US 6,458,386 B1 · Medicaments based on polymers composed of methacrylamide-modified gelatin

Abstract

The present invention relates to a composition comprising a biopolymer matrix comprising cross-linked vinyl-derivatives of gelatin, or co-polymerized methacrylamide modified gelatin with vinyl-modified polysaccharides, or cross-linked vinyl-substituted polysaccharide and gelatin being physically entrapped in a semi-interpenetrating network. Preferably said polysaccharide comprises dextran or xanthan. The present invention also relates to a wound dressing or a controlled release device comprising said biopolymer matrix. Preferably said matrix is in the form of a hydrated film, a hydrated or dry foam, dry fibers which may be fabricated into a woven or non-woven tissue, hydrated or dry microbeads, dry powder, or covered with a semipermeable film so as to control the humidity of the wound covered with the dressing, with the permeability chosen so as to maintain this humidity within a therapeutically optimal window.

Claims21

Dependent claims

A composition containing a biopolymer matrix comprising constituents selected from the following:

a. a methacrylamide modified gelatin and a polysaccharide, wherein the gelatin is modified with methacrylamide side groups which are capable of being radically cross-linked;
or
b. a gelatin and a vinyl-substituted polysaccharide, wherein the polysaccharide is modified with vinyl side groups which are capable of being radically cross-linked;
or,
c. a methacrylamide modified gelatin and a vinyl-substituted polysaccharide wherein the gelatin has been modified with methacrylamide side groups which are capable of being radically cross-linked and the polysaccharide has been modified with vinyl side groups which are capable of being radically cross-linked;
wherein the respective matrix constituents are physically entrapped in the matrix, after radically induced cross-linking polymerization or radically induced cross-linking copolymerization, so that they form a semi-interpenetrating network.

3 more elements

A biopolymer matrix produced by a process comprising:

(a) providing a solution comprising:
(i) a methacrylamide modified gelatin and a polysaccharide, wherein the gelatin is modified with methacrylamide side groups which are capable of being radically cross-linked;
or
(ii) providing a solution comprising a gelatin and a vinyl-substituted polysaccharide, wherein the polysaccharide is modified with vinyl side groups which are capable of being radically cross-linked;
or,
(iii) providing a solution comprising a methacrylamide modified gelatin and a vinyl-substituted polysaccharide wherein the gelatin has been modified with methacrylamide side groups which are capable of being radically cross-linked and the polysaccharide has been modified with vinyl side groups which are capable of being radically cross-linked;
and
(b) radically inducing cross-linking polymerization or cross-linking co-polymerization of the side groups.

5 more elements

Dependencies are inferred from the claim text.

Medicaments based on polymers composed of methacrylamide-modified gelatin

Life of this patent

Medicaments based on polymers composed of methacrylamide-modified gelatin

Life of this patent

Abstract

Claims21