US 6,458,366 B1 · Compounds and methods for diagnosis of tuberculosis

Abstract

Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

Claims5

Dependent claims

A method for detecting M. tuberculosis infection in a biological sample, the method comprising:

(a) contacting the biological sample with a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:
346;
and
(b) detecting in the sample the presence of antibodies that bind to the poleptide, thereby detecting M. tuberculosis infection in the biological sample.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

09/072,596Filed 5 May 1998 · continuation in part

Priority

WO PCT/US96/1467530 Aug 1996

Granted

1 Oct 2002

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C12Q 1/6883
Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes: for diseases caused by alterations of genetic material
A61P 31/06
Antibacterial agents: for tuberculosis
C07K 14/35
From bacteria: from Mycobacteriaceae
C07K 16/1289
Gram-positive bacteria: mycobacteriaceae

Family

Application08/523,435Parent of this continuation · filed 1 Sep 1995

Application08/532,136Parent of this continuation-in-part · filed 22 Sep 1995

Application08/620,280Parent of this continuation-in-part · filed 22 Mar 1996

Application08/658,800Parent of this continuation-in-part · filed 5 Jun 1996

Application08/680,574Parent of this continuation-in-part · filed 12 Jul 1996

Application08/729,622Parent of this continuation-in-part · filed 11 Oct 1996

Application08/818,111Parent of this continuation-in-part · filed 13 Mar 1997

Application08/942,341Parent of this continuation-in-part · filed 1 Oct 1997

Application09/024,753Parent of this continuation-in-part · filed 18 Feb 1998

Application08/532,136Parent of this continuation

US 6,338,852 B1Related patent

US 6,458,366 B1This patent

From the US filing history. Foreign family members aren’t listed.

Compounds and methods for diagnosis of tuberculosis

Life of this patent

Compounds and methods for diagnosis of tuberculosis

Life of this patent

Abstract

Claims5