Method to produce inactivated w/o emulsion adjuvated vaccines
AssigneeAkzo Nobel N.V.
InventorsCarla Christina Schrier, Eric Onno Rijke
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Abstract
The present invention is directed to a method to prepare an inactivated w/o emulsion adjuvated vaccine, wherein an aqueous solution comprising one or more inactivated angigens is mixed under mild conditions with a ready-made w/o emulsion. Preferably the vaccine is prepared just prior to vaccination. The aqueous solution and w/o emulsion are stirred or shaken by mechanical means or by hand. The present invention also relates to a kit of parts for use in a method according to the invention.
Claims8
A method for preparing an inactivated, water-in-oil emulsion adjuvated vaccine, comprising mixing an aqueous solution comprising one or more inactivated antigens under mild conditions with a ready-made water-in-oil emulsion.
A kit of parts that can be used for the preparation of an inactivated water-in-oil emulsion adjuvated vaccine just prior to vaccination, said kit comprising at least one dosage of inactivated antigen and a separate dosage of water-in-oil emulsion.
Dependencies are inferred from the claim text.